Amyloidosis Treatment in India
Amyloidosis treatment in India is a highly competitive field. it comes to the number of doctors, hospitals, and pharmaceuticals, India ranks pretty well in the amyloidosis treatment field. that is because India has a strong focus on developing and creating medical technologies that are required for the field of Amyloidosis treatment.
Amyloidosis Treatment in India: The Best Place to be in Amyloidosis?
With over a billion people in India, the population is rapidly growing.
In the face of such incredible growth in population, it is quite probable that the number of people suffering from amyloidosis will increase as well.
How is amyloidosis treated India?
It starts in soft tissues, and spreads to other organs in the body.
This kind of cancer is fatal.
The treatment for amyloidosis depends on how advanced it has reached.
There are two ways in which amyloidosis can be diagnosed:
The test called a biopsy is a surgical procedure in which an area of your tissue is cut out, removed and tested for amyloidosis. A needle is used to cut a small area of tissue from the tumour or organ where the amyloid has spread.
Amyloidosis is caused by a problem with proteins in your body.
There are two types of amyloidosis:
A blood test will show that your blood has amyloid, and a biopsy will show the amyloid in your bone, heart, lungs and other organs.
Your body starts to attack the blood vessels and make them leak.
There are many types of amyloidosis, and not all of them are caused by an underlying problem. If there is a problem with the production of proteins, it’s called primary amyloidosis.
There are two kinds of amyloidosis.
Primary amyloidosis is a disease that causes your body to start making too much protein. The protein is called amyloid and it gets into the organs in the body. The amyloid builds up in your organs and can cause them to change.
Systemic amyloidosis is a disease that causes amyloid proteins to build up in your blood. The blood stops flowing in to the organs.
As it builds up in the blood vessels, it can stop them from working and cause them to leak. This can be a serious problem that causes organs to stop working.
Amyloidosis treatment in India includes:
- – Bone Marrow Transplantation (BMT)
- – Orthopedic Surgery
- – Chemotherapy and Palliative Treatment
- – Pain management
- – Radiation Therapy
- – Dialysis
Some of the best places to go for amyloidosis treatment in India are:
- – National Institute of Amyloidosis and Allied Diseases (NIAID)
- – Rajiv Gandhi Cancer Institute and Research Centre (RGCI)
- – St. John’s Medical College Hospital (SJMCH)
- – Seth G S Medical College and KEM Hospital
- – Tata Memorial Hospital
- – Apollo Hospitals, Hyderabad
- – Sree Chitra Thirunal Institute for Medical Sciences and Technology
Types of Amyloidosis Treatment in India
The most common types of Amyloidosis treatment in India are:
The treatments for Amyloidosis vary depending on the type of amyloidosis.
What is Amyloidosis?
protein can develop in a variety of places, including the intestine, kidney, heart, and nerves.
The high protein level in urine
Symptoms of kidney failure include swelling in the ankles and feet and swelling around the eyes
Types of amyloidosis
Hereditary amyloidosis is responsible for causing eye abnormalities, motor neuropathy problems, carpel tunnel syndrome, and peripheral sensory problems.
Amyloid protein deposition may result in a heterogeneous disease, which varies in etiology, clinical presentation, and prognosis. Clinically, amyloidosis can be classified into 5 categories based on clinical manifestations.
1. Familial amyloidosis
Familial amyloidosis with transthyretin (ATTR) amyloidosis and familial amyloidotic polyneuropathy (FAP) are 2 types of primary systemic amyloidosis, which account for almost 90% of cases.
In ATTR amyloidosis, the *TTR* gene mutation is a single nucleotide change, which is related to the Glu122Lys amino acid substitution.
ATTR protein consists of 3 domains: N-terminal, intercalated domain, and C-terminal domain.
1\) Non-ATTR type with dominant mutation (Val30Met, Thr60Ala, and Ile71Tyr)
ATTR Val30Met is the most common *TTR* mutation (accounting for approximately 80% of
Causes to amyloidosis
Typically, these proteins build up in the tissue space between cells.
Amyloidosis begins in the bone marrow.
This causes the accumulation of antibodies in the blood which gradually accumulate in the tissues as amyloid.
Amyloidosis is more likely to occur in people who:
- are over 50 years old
- Have a family history of amyloidosis
- have multiple myeloma
- have an inflammatory disease or chronic infection
Symptoms of amyloidosis
Symptoms depend on the organ affected.
Some common symptoms are –
- Heartbeat
- weakness
- fainting spells
- Diarrhea
- weight loss
- swelling in the feet or ankles
- an enlarged tongue
- shortness of breath
- dizziness on standing
- severe fatigue
- tingling or numbness in the feet or hands
- feeling full after eating a small amount of food
specific groups of symptoms called syndromes
Malabsorption (problems absorbing nutrients from food)
Heart failure (inability of the heart to pump enough blood to meet the body’s needs)
Nerve damage or autonomic neuropathy can affect involuntary functions of the body, including sweating and heart rate.
Nerve damage or peripheral neuropathy can affect the peripheral nervous system (PNS). The peripheral nervous system is responsible for transmitting information between the spinal cord and the brain and the rest of the body.
Nephrotic syndrome is a condition where there is an excessive accumulation of protein in the kidneys
Diagnosis of amyloidosis
Urine and blood tests help detect amyloid protein. A specific type of biopsy procedure varies from patient to patient.
Diagnosis of amyloidosis is usually straightforward. The protein amyloid fibrils usually stain blue/green with iodine potassium iodide and red with thioflavin S.
The most common methods for the detection of protein amyloidosis include immunohistochemistry and mass spectrometry.
The best approach for the identification of amyloid fibril protein is the analysis of amyloid protein sequence.
In the past decade, genetic studies have revealed the major amyloidosis protein types. The most common types of amyloidosis in humans include AA, AL, ATTR, and TTR.
In this article, we will summarize the identification of the different types of amyloid fibrils.
Diagnosis of amyloidosis is usually straightforward.
The protein amyloid fibrils usually stain blue/green with iodine potassium iodide and red with thioflavin S.
The most common methods for the detection of protein amyloidosis include immunohistochemistry and mass spectrometry.
The best approach for the identification of amyloid fibril protein is the analysis of the amyloid protein sequence.
In the past decade, genetic studies have revealed the major amyloidosis protein types. The most common types of amyloidosis in humans include AA, AL, ATTR, and TTR.
Treatment of amyloidosis
There is no cure for the condition of amyloidosis. The doctor will recommend certain treatments to stop the growth of amyloid-forming proteins and to manage the symptoms in the patient.
A liver transplant helps prevent disease in people who suffer from hereditary amyloidosis
One method of amyloid clearance is the use of antibodies to the amyloid protein, which can block the deposition of amyloid in the tissue.
Some other treatments that may help with the symptoms include:
Diet modification for people with gastrointestinal amyloidosis
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